DOCnet
Diabetes & obesity at the crossroads between Oncological and Cardiovascular diseases – a system analysis NETwork towards precision medicine

    

ABOUT THE PROJECT

This research project exploits a network of emblematic regional research, development & innovation infrastructures and is hosted by the Faculty of Medicine of the University of Porto and its Cardiovascular Research Centre (UnIC), and by Centro Hospitalar São João, E.P.E. (CHSJ), the Institute of Public Health from the University of Porto (ISPUP) and its Epidemiology Research Unit (EPIUnit) and the Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) an affiliated research unit of the Institute of Research and Innovation in Health (I3S).

AIM

The decision to jointly study oncological and cardiovascular diseases represents a matter of public health interest. Oncological and cardiovascular diseases are the most prevailing diseases and the 1st and 2nd cause of mortality, respectively, in the Western World. Its growing prevalence is related to obesity epidemics and obesity-related comorbidities.

Our main aim is to perform an integrated management of clinical, molecular and biochemical biobank data that enables a systems biology and public health approach to precision medicine in oncological and cardiovascular diseases, focusing on the role of DM and obesity, and using bioinformatics network analysis.

Specifically we aim to:

  1. Expand and upgrade the collection of clinical and biological sample database of oncological and cardiovascular diseases;
  2. Implement an information technology tool and software that gathers and integrates clinical data that is scattered by different software applications;
  3. Carry out a full characterization of plasma, myocardial, adipose and tumour tissue biopsies in subgroups of patients based on comorbidities such as type 2 DM and obesity;
  4. Perform a bioinformatic approach to integrate clinical with the corresponding molecular data and thus conferring a potential pathophysiological, therapeutic prognostic value to these data;
  5. To assess omics-derived markers association with the incidence, progression or activation of metabolic and other signalling pathways in gastric and thyroid cancers and intermediate phenotypes in the cardiovascular diseases continuum in the general population.
 

CONSORTIUM

Institutions

UNICFMUPIPATIMUPISPUP

 

Affiliated institutions

 

TEAM

Project Coordinator

Adelino Leite Moreira

Adelino Leite Moreira

Full Professor of Physiology, Pathophysiology & Cardiothoracic Surgery, Faculty of Medicine of the University of Porto
Cardiothoracic Surgeon, Centro Hospitalar de São João, EPE. Porto
Coordinator of Cardiovascular Research Centre (UnIC)

Orcid: 0000-0001-7808-3596

Research Line Leaders

Fátima Carneiro

Fátima Carneiro

Full Professor of Pathology, Faculty of Medicine of the University of Porto
Head of the Department of Pathology, Centro Hospitalar de São João, EPE. Porto
Senior Researcher at IPATIMUP/I3S

Orcid: 0000-0002-1964-1006

Henrique Barros

Henrique Barros

Full Professor at the Department of Clinical Epidemiology, Predictive Medicine and Public Health, Faculty of Medicine of the University of Porto
Coordinator of EPIUnit - Epidemiology Research Unit, Institute of Public Health of the University of Porto

Orcid: 0000-0003-4699-6571

Research Line Co-Leaders

Paulo Bettencourt

Paulo Bettencourt

Full Professor of Internal Medicine, Faculty of Medicine of the University of Porto

Orcid: 0000-0003-1638-3993

Ana Cristina Santos

Ana Cristina Santos

Professor at the Department of Clinical Epidemiology, Predictive Medicine and Public Health, Faculty of Medicine of the University of Porto
Researcher - EPIUnit - Epidemiology Research Unit, Institute of Public Health of the University of Porto

Orcid: 0000-0002-2992-5299

Davide Carvalho

Davide Carvalho

Associate Professor of the Medicine (Endocrinology), Faculty of Medicine University of Porto

Orcid: 0000-0002-3156-3741

 

PUBLICATIONS

  1. Gastric carcinoma with lymphoid stroma in the era of the immune context and immunotherapies
  2. Cardiac compliance is acutely modulated through cGMP-PKG signalling

Publicações da UnIC

  1. Bastos P, Trindade F, Ferreira R, Leite-Moreira A, Falcao-Pires I, Manadas B, et al. EDTA-functionalized magnetic nanoparticles: A suitable platform for the analysis of low abundance urinary proteins. Talanta. 2017; 170:81-8.
  2. Francisco C, Neves JS, Falcao-Pires I, Leite-Moreira A. Can Adiponectin Help us to Target Diastolic Dysfunction? Cardiovasc Drugs Ther. 2016;30(6):635-44.
  3. Guerra M, Mendes-Ferreira P, Adao R, Pereira E, Vieira M, Lourenco AP, et al. Improvement in left intraventricular pressure gradients after aortic valve replacement in aortic stenosis patients. Exp Physiol. 2017;102(4):411-21.
  4. Mendes-Ferreira P, Santos-Ribeiro D, Adao R, Maia-Rocha C, Mendes-Ferreira M, Sousa-Mendes C, et al. Distinct right ventricle remodeling in response to pressure overload in the rat. Am J Physiol Heart Circ Physiol. 2016;311(1):H85-95.
  5. Pintalhao M, Castro-Chaves P, Vasques-Novoa F, Goncalves F, Mendonca L, Fontes-Carvalho R, et al. Relaxin serum levels in acute heart failure are associated with pulmonary hypertension and right heart overload. European journal of heart failure. 2017;19(2):218-25.
  6. Trindade F, Ferreira R, Magalhaes B, Leite-Moreira A, Falcao-Pires I, Vitorino R. How to use and integrate bioinformatics tools to compare proteomic data from distinct conditions? A tutorial using the pathological similarities between Aortic Valve Stenosis and Coronary Artery Disease as a case-study. J Proteomics. 2017.
  7. Trindade F, Leite-Moreira A, Ferreira-Martins J, Ferreira R, Falcao-Pires I, Vitorino R. Towards the standardization of stem cell therapy studies for ischemic heart diseases: Bridging the gap between animal models and the clinical setting. Int J Cardiol. 2017; 228:465-80.

Publicações do IPATIMUP

  1. Savio A, Amaral AL, Nunes R, Ricardo S, Sarmento B, Almeida R, Tsukamoto H, das Neves J. A Mouse Intra-Intestinal Infusion Model and its Application to the Study of Nanoparticle Distribution. Front Physiol 2016; 7: 579. doi: 10.3389/fphys.2016.00579.
  2. Gullo I, Carneiro F, Oliveira C, Almeida GM. Heterogeneity in gastric cancer: from pure morphology to molecular classifications. Pathobiology 2017. doi: 10.1159/000473881.
  3. Alsina M, Gullo I, Carneiro F. Intratumoral heterogeneity in gastric cancer: a new challenge to face. Ann Oncol 2017; 28: 912-913. doi: 10.1093/annonc/mdx134.
  4. Gullo I, Gonçalves G, Pinto ML, Athelogou M, Almeida GM, Huss R, Oliveira C, Carneiro F. "Gastric cancer with lymphoid stroma: a study of clinico-pathological profile, Epstein-Barr virus, microsatellite instability, tumour immune microenvironment and PD-L1 status". 4th ImmunoTherapy of Cancer Conference (ITOC4). J Immunother Cancer 2017, 5(Suppl 1). doi: 10.1186/ s40425-017-0219-4.

Publicações do ISPUP

  1. Cabral M, Fonseca MJ, González-Beiras C, Santos AC, Correia-Costa L, Barros H. Maternal smoking: a life course blood pressure determinant? Nicotine & Tobacco Research, 2017, 1-7 doi: 10.1093/ntr/ntx117
  2. Fonseca MJ, Severo M, Lawlor DA, Barros H, Santos AC. Newborn weight change and childhood cardio-metabolic traits – a prospective cohort study
  3. Fonseca MJ, Severo M, Lawlor DA, Barros H, Santos AC. Understanding the direct and BMI-mediated association between birth weight and childhood cardio-metabolic health – findings from a prospective birth cohort
  4. Rocha V, Ribeiro AI, Severo M, Barros H, Fraga S. Neighbourhood socioeconomic deprivation and health-related quality of life: a multilevel analysis.

EVENTS

Coming soon

NEWS

Professora Fátima Carneiro, líder de uma das linhas de investigação do projeto DOCnet, é eleita a patologista mais influente do mundo

Ver notícia

 

ESC 2018

A UnIC – Unidade de Investigação e Desenvolvimento Cardiovascular da Faculdade de Medicina da Universidade do Porto (FMUP), esteve mais uma vez presente no Congresso Europeu de Cardiologia 2018, que decorreu de 25 a 29 de agosto, em Munique.

“Prognostic value of cardiac troponin after coronary artery bypass grafting” é o título do trabalho que foi apresentado pela Dr.ª Francisca Saraiva. O objetivo deste estudo retrospetivo foi avaliar o impacto prognóstico das troponinas cardíacas após a cirurgia de revascularização do miocárdio. A Drª Ana Filipa Ferreira apresentou o trabalho intitulado “Postoperative atrial fibrillation after coronary artery bypass grafting surgery”, onde descreve a importância do desenvolvimento de scores preditivos de fibrilhação auricular após cirurgia cardíaca. A Drª Francisca Saraiva e a Drª Ana Filipa Ferreira são ambas estudantes de doutoramento da FMUP e investigadoras da UnIC.

 

Professor Adelino Leite Moreira, coordenador do projeto DOCnet, vence prémio de excelência na investigação científica

Ver notícia

 

Professora Fátima Carneiro, líder de uma das linhas de investigação do projeto DOCnet, integra equipa que publicou recentemente um artigo na prestigiada revista de gastroenterologia Gut

Ver notícia

 

I NoTeS Congress

Encontram-se abertas as inscrições para o I NoTeS Congress - Novel Therapeutic Strategies for Noncommunicable Diseases que decorrerá no Auditório CIM da Faculdade de Medicina da Universidade do Porto (FMUP), nos dias 22 e 23 de junho de 2018.

As doenças mais comuns da civilização moderna, que frequentemente resultam de uma incompatibilidade entre a fisiologia humana e o estilo de vida atual, são não-comunicáveis. Constituem exemplos a doença coronária, a hipertensão, a diabetes tipo 2, o cancro e a obesidade.

O Congresso NoTeS pretende fomentar a discussão nesta temática, tendo por base os mais recentes avanços científicos na interação estilo de vida/doença, a par das novas abordagens que visam diminuir o risco e a progressão das principais doenças crónicas.

Mais informações e inscrições em: https://notescongress.wixsite.com/noncomdiseases

 

DOCnet Consortium Meeting

The first meeting of the project DOCnet (Diabetes & obesity at the crossroads between Oncological and Cardiovascular diseases – a system analysis NETwork towards precision medicine - NORTE-01-0145-FEDER-000003) took place on May 4th, 2017 at the Faculty of Medicine of the University of Porto.

In the morning session, the project coordinator introduced the scientific concept and main objectives of DOCnet. In addition, each research line (RL) coordinator presented the specific objectives, as well as the scientific outputs and achievements obtained during the 1st year of its execution. In the end of each presentation, there were extensive discussions with the purpose of clarifying the main scientific objectives of each RL and defining strategies to optimize the links and interactions between the RLs.

In the afternoon session, some of the work performed in the context of DOCnet was presented by the involved investigators aiming to foster integration of the scientific activities.

This event was a success as it promoted an active discussion of the ongoing and future research activities within DOCnet while also allowing the interaction of all members of the consortium, as defined in the networking strategies.

All scientific activities are being carried out  accordingly to the proposed timeline and the milestones of each research line (RL), namely: i) RL1 - A multi-omics approach to decipher diabetes-related molecular targets in cancer: a step towards precision medicine (co-promotor: IPATIMUP – I3S; Responsible researcher: Fátima Carneiro); ii) RL2 - Cardiovascular phenomapping in the continuum from risk population to end-stage disease (co-promotor: UnIC – FMUP; Responsible researcher: Adelino Leite-Moreira), and iii) RL3 - Integration of metabolic risk markers into the expo some for prediction and prevention of oncological and CV diseases (co-promotor: ISPUP – UP; Responsible researcher: Henrique Barros).

 

ESC 2017

UNIC researchers, one of the project partners, was present in the last ESC, held in Barcelona between 26-30 august. The world’s largest cardiovascular congress with over 500 experts sessions and more than 4 500 abstracts contributing to the advancement of cardiovascular medicine worldwide.

Renowned for its scientific excellence, the congress was a great opportunity for our researchers to present some of the results of the Project.

NEWSLETTERS

Coming soon

 

CONTACT

Consortium Leader

Adelino Leite Moreira

Full Professor / Coordinator of Cardiovascular Research Centre (UniC)
Faculty of Medicine, University of Porto
Phone: (+351)225 553 644

Please contact us using contact form below.